Effects of the combined treatment with the minimal effective dose of FSH and the various levels of ICSH (LH) on the reproductive organ system of hypophysectomized immature female rats
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Effects of the combined treatment with the minimal effective dose of purified swine FSH (200γ) and the various levels of purified sheep ICSH (LH) on the ovaries and the uteri of hypophysectomized immature female rats were studied. The experimental conditions were the same as that of the previous report<SUP>5)</SUP> except that FSH and ICSH were injected separately into the underskin at different sites of the body.<BR>On injection of 200γ of FSH alone, ovaries and uteri were increased in weight. This dose of FSH caused the development of follicles with stimulated internal theca cells and without repair of the deficient interstitial cells. The ovarian and uterine weights were barely increased by the large dose (1 mg) of ICSH. The most conspicuous effect of ICSH was the stimulation of the interstitial tissue. The augmentation of the effect of 200γ of FSH on the increase of ovarian and uterine weights was not conspicuous by combination with ICSH. The histological examination demonstrated that the interstitial tissue was highly stimulated and the follicular growth with the development of internal theca cells was somewhat augmented, but no thecal luteinization nor formation of corpus luteum was detected. The stimulative effect of FSH on estrogen secretion, estimated by the uterine development, was not so increased by the combined treatment of ICSH. The authors (1957) found that FSH is the potent substance to induce ovulation in adult rats<SUP>8)</SUP>.<BR>By these results, it would be said that the main effect of ICSH on the ovary may be the stimulation of interstitial tissue, and FSH might play more important role to cause the formation of corpus luteum.
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日本繁殖生物学会 | 論文
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