Studies on shortening of estrous cycle in 4-day cyclic mice:IV. Effect of male proximity on theestrogen secretion

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The effect of male proximity on the estrogen secretion was studied using the 4-day cyclic mice. The animals were housed in artificially illuminated animal rooms (light: from 5 a.m. to 7 p.m.). The female mice were divided into 2 groups. The animals of the first group were placed in cages each of which had a wire-net separated rooms for male mice. The mice of both sexes were putseparat ely in these cages from 2 p. m. on the day of vaginal estrous stage. The other groups served as a control without male mice. 1) The mice of both groups were examined for appearance of vaginal estrous stage after being ovariectomized at the several stages during diestrus and metestrus. Appearance of the vaginal estrous stage indicated earlier secretion of ertsogen in the females placed adjacent to the male mice as compared with the control mice (Fig. 4). 2) Onset of the vaginal estrous stage was earlier in the females placed adjacent to the male mice as compared with the control mice (Fig. 2). 3) The wet weight of the uterus in the treated groups gained weight more earlier than in controls (Fig. 3). Thus, our findings may indicate that estrogen secretion in female mice is induced by male proximity.
日本繁殖生物学会の論文