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To evaluate whether genetic abnormalities can serve as a molecular biological marker for the risk assessment related to the development of multiple cancers, detection of allelic loss and immunohistochemical analyses were investigated in oral and pharyngeal cancers of patients with second cancers in other organs. Three microsatellite markers, D3S 1067, IFNA and D9S171, were used to study the loss of heterozygosity (LOH) of 3p21 and 9p21 in 20 primary cancers of oral and pharyngeal origin. There were 18 informative cases, and LOH was detected in 14 out of 18 (78%) DNA samples obtained from cancer specimens when at least one marker was used. The frequency of LOH was correlated with the clinical stages of the patients, and it was extremely high (100%) in hypopharyngeal cancers. Specimens from oral and pharyngeal cancers as well as second malignancies of the same patients were analyzed by immunohistochemistry to detect the expression of p21 (Waf-1) and Bcl-2. We observed the expression of Bcl-2 and disappearance of the expression of Waf-1 in both early and advanced carcinomas. These data indicate the possibility that the detection of 3p and/or 9p LOH in a cancer may serve as a good molecular marker for the assessment of second cancer risk in the same patient.
- 日本口腔・咽頭科学会の論文
日本口腔・咽頭科学会 | 論文
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- Etiological implication and prognostic significance of genetic alterations in patients with cancer of the tongue.