Etiological implication and prognostic significance of genetic alterations in patients with cancer of the tongue.
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A loss of heterozygosity (LOH) and a replication error (RER) in squamous cell carcinoma of the tongue were studied by using 8 microsatellite markers. LOH at 3p and/or 9p was observed in 5 out of 18 samples (28%) that could be evaluated from the 30 tongue cancer specimens examined. No significant difference was found between the survival rates of patients with LOH positive tumors and those of patients with LOH negative tumors. RER was detected in 7 out of 29 samples (24%) that could be evaluated, at one to five loci. The number of patients with RER positive tumors was higher in the younger group (under 45) than in the older group (over 45) (p=0.018). The frequency of RER was not correlated with the clinical stage of the patient and tumor size; however, it was apparently high in the N1 cases. The survival rates of the patients with RER negative tumors was significantly low compared with that of patients with RER positive tumors (p<0.05), and the prognoses of the patients with RER positive tumors were obviously good with no recurrent tumors. The amount of alcohol consumption by patients with RER positive tumors was significantly lower than that of patients with RER negative tumors (p=0.002), and the amount of smoking was also lower among patients with RER positive tumors.<BR>These results indicate that the allelic loss of 3p and/or 9p is not apparently correlated with the malignant transformation of tongue cancers; however, the presence of RER is a prognostic factor independent of other clinicopathological factors. Moreover, it is likely that an intrinsic factor such as DNA mismatch error or instability of the genome is correlated with the carcinogenesis of a subgroup of tongue cancers besides environmental factors such as tobacco and alcohol.
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日本口腔・咽頭科学会 | 論文
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- Etiological implication and prognostic significance of genetic alterations in patients with cancer of the tongue.