Influenza Vaccination for Asthmatic Children: Intranasal Inactivated Influenza Vaccine Induced Serum Antibody Responses without Change in Nasal Symptom.

概要

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Influenza infection is known to cause serious respiratory symptoms especially in asth-matic patients. Recently some reports say intranasal inoculation of influenza vaccine induces secretary IgA antibody in respiratory mucosa which acts as main barrier to local spread of the virus without major adverse effects. We studied whether it can induce antibody and affect nasal symptoms in allergic patients. We employed 22 children (ran-ging 3 to 12 years old) with allergic disease including 75% of allergic rhinitis. Mixture of three inactivated influenza viruses (A/Yamagata/32/89, A/Kitakyushu/159/93, B/Bang-kok/163/90) were given intranasally once a month twice. Nasal symptom scores were assessed monthly. Serum HI titers to each virus were measured and staining of nasal smear were analyzed before and 2 months after initial inoculation. Results showed se-rum HI titers to all of three viruses increased significantly, whereas no significant change was seen neither in nasal symptom scores nor in nasal smear findings. No sys-temic side effects were seen. These data suggest intranasal vaccination of influenza vi-rus to allergic patients can induce serum antibody response without systemic or local ad-verse reactions.
一般社団法人国立医療学会の論文