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Using leukocyte migration inhibition test, the activity of serum immunosuppressive factor was determined in 50 patients with malignant lymphoma. The factor was observed in 40% of patients with malignant lymphoma. The percent blocking index (% BI) was -7.3% in four patients with stage I, +7.4% in seven patients with stage II, +12.8%6 in 15 patients with stage III, and +17.4% in 24 patients with stage IV. The activity in patients with localized disease was significantly higher than the activity in patients with extensive disease (p<0.01). Serial determination of % BI was correlated with the clinical course, and the % BI was inversely correlated with the skin test response to PPD. Serum immune complex was observed in 50% of patients with malignant lymphoma, and the percentage of positive cases was higher in patients with extensive disease than in patients with localized disease. Therefore, we may conclude that serum immunosuppressive factor appears to serve as a parameter for malignant lymphoma.
一般社団法人国立医療学会の論文