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The clinical features of 7 cases of germinoma (so-called two cell pattern pinealoma) were reviewed;4 histologically verified and 3 histologically non-verified. Among these 7 cases, we experienced 3 disseminated ones, but only in the spinal region. A course of radiotherapy for these 3 cases was given and we applied routinely irradiation for the whole brain, but didn't apply whole cerebrospinal axis irradiation. The general prognosis of all cases was good.Among our cases, case 6 of germinoma in the right basal ganglia and it's surrounding tissue had precocious puberty with abnormal levels of HCG. In addition to excessively high concentrations of HCG in the urine, serum and cerebrospinal fluid (CSF), elevated plasma LH and decreased plasma FSH were revealed. Craniotomy was performed and this case was diagnosed as germinoma histologically. However, syncytiotrophoblasts generally observed in the choriocarcinoma were seen in it's tissue. By means of peroxidaselabeled antibody method, the authors proved HCG in syncytial cells of the tumor's tissue.It is well known that germinomas are extremely radiosensitive and some of them rapidly disappear by follow-up CT scanning after irradiation with as little as 2000 rads. The authors would like to emphasize;1) Histological classification has been well established by introduction of the germ cell tumors including germinomas and choriocarcinoma. 2) preoperative diagnosis has been made more accurate by tumor-marker such as alphafetoprotein and HCG. 3) Operative procedures have been refined by microsurgical techniques.
一般社団法人国立医療学会の論文

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一般社団法人国立医療学会 | 論文

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スポンサーリンク

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一般社団法人 国立医療学会 | 論文

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一般社団法人国立医療学会 | 論文