Effects of a single injection of gonadotropins on the ovarian function in late pregnancy in rats.

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The effects of a single injection of synthetic luteinizing hormone releas-ing hormone (LH-RH), PMSG and HCG in late pregnancy on delivery and post-partum ovulation in rats were investigated. The hormones were injected subcutaneously (sc) after day 17 of pregnancy. Ten μg/rat LH-RH prolonged pregnancy, while 10, 20 and 50 iu/rat PMSG and 20 IU/rat HCG caused premature delivery. Ten μg LH-RH and 20 IU HCG did not affect the number of shed ova and ovarian weight after delivery, whereas 50 IU PMSG in-creased both of them. The time relationship between delivery and post-partum ovulation did not change with LH-RH, HCG or PMSG treatment. LH level in serum increased within 1h (1046.5±237.70 ng/ml, Mean±SE) after 10 μg LH-RH treatment in late pregnancy and decreased to that of the control 2h later (121.5±19.23 ng/ml). FSH level increased soon after the LH-RH treatment (983.0±73.70ng/ml) and remained in the high level as long as 3h after treatment.
日本繁殖生物学会の論文