The study on the sexual maturation of thefemale rat.period.:Serum levels of LH and FSH duringthe first ovulation
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It is well known that the abrupt increase of uterine weight accompanied by the "ballooning" with the accumulation of inner fluid occurs in rats before the time of first ovulation.<BR>To clarify the relationship between uterine development and blood gonadotropin levels during the first ovulation period, rats were killed by decapitation under light ether anesthesia at 10:00, 15:00, 17:00 or 19:00 h on 5 weeks of age. Serum gonadotropin (LH and FSH) levels were measured by radioimmunoassay.<BR>The animals were classified into two groups, ovulated and unovulated: Unovulated group was subdivided into three subgroups by the degree of the uterine development as follows;<BR>a) "Non-ballooned uterus": less than 100 mg with no fluid.<BR>b) "Semi-ballooned uterus": 100150 mg with a small amount of fluid.<BR>c) "Ballooned uterus": more than 150 mg filled with fluid.<BR>There was little change in serum gonadotropin levels during the time of "Non-ballooned", "Semi-ballooned" and the morning of "Ballooned".<BR>In the "Ballooned uterus" group serum levels of both LH and FSH in the afternoon were clearly classified into two types, remarkable high levels ("Activated"), and low basal levels ("Non-activated") similar with the other anovulated groups. In the "Activated" group, LH levels reached a peak at 17:00 h followed by a significant decrease at 19:00 h, while high FSH levels were maintained through 15:00 h to 19:00 h.<BR>When the uterine weights during 15:00 to 19:00 h were pooled, the uterine weight of the activated group was significantly heavier (p<0.01) than that of non-activated group.<BR>In "Ovulated" group, LH had already decreased to the basal levels while FSH were still higher than the levels before GTH surge occurred.<BR>The authors acknowledge the gift of rat LH and FSH radioimmunoassy materials from the Rat Pituitary Hormone Distribution Program of the National Institute of Arthritis, Metabolism and Digestive Diseases.
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