Induction of ovulation by exogenous progesterone in 4-day cyclic mice (IVCS strain); injection on the day of diestrus stage

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EVERETT (1948) demonstrated that in the 5-day cyclic rat, progesterone could induce ovulation 24 hours early when given nearly midday on the day of stage late V (the previous day of proestrus). On the other hand, no advance of ovulation time is obtained in 4-day cyclic rats injected on 24 hours before the expected proestrus. Authers tried to induce the ovulation by injection of progesterone on the day of stage V (diestrus) in the 4-day cyclic mice (IVCS strain) under the constant lighting from 5 a. m. to 7 p. m.. The results obtained are as follows: 1) In the 4-day cyclic mice, the single subcutaneous injection of progesterone (0.25 mg and 0.5 mg/mouse) at 7 p. m. on the day of stage V induced the ovulation on the next day as high ratio (Figs. 1, 2 and 5). 2) Induced ovulation by progesterone (0.5 mg/mouse) was observed 1315 hrs. after the injection, it was injected singly and subcutaneously at 7 p. m. on the day of stage V in 4-day cyclic mice (Fig. 4). 3) In the 4-day cyclic rats (Wistar-Imamichi strain), the subcutaneous single injection of progesterone (1.5 mg and 3 mg/rat) on the day of stage V did not cause induction of ovulation on the next day.
日本繁殖生物学会の論文