Effect of NK433 (Lanperisone hydrochloride) on the masseter muscle blood flow response in rat

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Pathogenic changes of muscle pain in temporomandibular disorder (TMD) patients are unknown. Local ischemia, however, seems to be one of the important factors of the muscle pain. Recently, the pharmacologic effect of centrally acting muscle relaxant, with vasodilation actions, on muscle pain has been reported. We investigated blood flow changes at rest of the masseter muscle in anesthetized rat during pre- and post-injection of NK433 (a new centrally acting muscle relaxant: Lanperisone hydrochloride) using a laser Doppler meter. Responses of post-exercise hyperemia induced by tetanic contracture were also studied.The results showed that the blood flow at rest of the masseter muscle increased for two minutes after injection. The half-time period of post-exercise hyperemia induced by tetani contraction was significantly shortened until 30 minutes after injection.These results suggested that a therapeutic effect of NK433 on TMD muscle pain might be available with its increasing blood flow action in the skeletal muscle.
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