:Cartilaginous degeneration and bone resorption
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概要
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Chronic joint degenerative changes as osteoarthritis and/or rheumatoid arthritis often exhibit temporomandibular joint (TMJ) involvement accompanied by pain and dysfunction. The pathogenesis of these conditions remains poorly understood, but important insights may be provided by suitable animal models of the degenerative joint diseases. The purpose of this study was to develop and histologically characterize an animal model of type II collagen antigen induced arthritis of the temporomandibular joint (TMJ).<BR>Arthritis was induced with an intra-articular injection of type II collagen with Freund's adjuvant in previously sensitized Sprague-Dauley (S. D. ) rats (n=5). The booster immunization was performed a total of 5 times into the articular cavity including the first time. Sham-treated rats with saline solution injection were used as a control (n=5). The TMJs were retrieved <I>en bloc</I> at 63 days after post-challenge for histological examination.<BR>Type II collagen antigen treated TMJs demonstrated degenerative changes of the articular cartilaginous structure, including thickening of superficial fibrous layer, decrease of proliferative layer, indistinctness of hypertrophic layer, and decrease of the whole thickness of the cartilaginous cover of the mandibular condyle. The size of the bony component of the condyle decreased with atrophic changes.<BR>This animal model will be useful for understanding the pathologic course of degeneration of the cartilaginous structure and bone resorption of the mandibular condyle with chronic arthritis of the TMJ.
- 一般社団法人 日本顎関節学会の論文
一般社団法人 日本顎関節学会 | 論文
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