Effect of bFGF on the growth of the rat mandibular condyle in organ culture.
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概要
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The present study was carried out to investigate histologically and histometrically the effect of basic fibroblast growth factor (bFGF) on the growth of the rat mandibular condyle in organ culture. The mandibular ondyles were removed from rats immediately after birth, and then cultured for 1 to 8 days in 2 kinds of media, namely serumless BGJb (Group 1) and serumless BGJb with bFGF 100ng/ml (Group 2). Histologically, the mesenchymal cells in the layer of proliferation in Group 2 at 6 and 8 days showed a marked increase in cell number compared with those in Group 1. Histometrically, the size of the mandibular condyles and the thickness of the layers of articular surface and proliferation in Group 2 at 8 days were significantly greater than those in Group 1, suggesting that bFGF had stimulated the proliferation of mesenchymal cell which had resulted in an increase of the number of chondrocytes in the layers of differentiation and hypertrophy there by leading to the enlargement of the condylar size.
- 一般社団法人 日本顎関節学会の論文
一般社団法人 日本顎関節学会 | 論文
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