Total Synthesis and Chemical Biology of the Sarcodictyins.
スポンサーリンク
概要
- 論文の詳細を見る
The sarcodictyins A-F and eleutherobin comprise a family of marine-derived diterpenoids with potent cytotoxicities against various tumor cell lines. Investigations have revealed that several of thess compounds exert their cytotoxic effects through tubulin binding in a mechanism analogous to that of the clinical anticancer drug taxol<SUP>TM</SUP>. The biological importance, challenging molecular architecture, and relative scarcity of these natural products have prompted several groups to undertake their total chemical synthesis. In this review, we summarize the current synthetic efforts and examine the preliminary structure-activity relationships which have emerged from early combinatorial libraries.
- 社団法人 日本薬学会の論文
社団法人 日本薬学会 | 論文
- Bioactive Constituents from Chinese Natural Medicines. XXXVI. Four New Acylated Phenylethanoid Oligoglycosides, Kankanosides J1, J2, K1, and K2, from Stems of Cistanche tubulosa
- Absolute Stereostructures of Olibanumols A, B, C, H, I, and J from Olibanum, Gum-Resin of Boswellia carterii, and Inhibitors of Nitric Oxide Production in Lipopolysaccharide-Activated Mouse Peritoneal Macrophages
- Medicinal Flowers. XXX. Eight New Glycosides, Everlastosides F—M, from the Flowers of Helichrysum arenarium
- Triterpenoid Saponins from the Stem Bark of Acanthopanax brachypus HARMS
- Mild Deprotection of Methylene Acetals in Combination with Trimethylsilyl Triflate–2,2′-Bipyridyl