Revised stereostructure for (+)-roemecarine and synthesis of (.+-.)-, (+)-, and (-)-roemercarine and (.+-.)-epiroemecarine.
スポンサーリンク
概要
- 論文の詳細を見る
The stereostructure of (+)-roemecarine, a new 1-benzyl-1, 2, 3, 4-tetrahydroisoquinoline having a hydroxyl group at the 4-position, was confirmed to be 1, 4-trans by synthesis of (±)-epiroemecarine (1) and (±)-roemecarine (5) via o-quinol acetates of isocodamine (4). Furthermore, (+)- and (-)-roemecarine (5) were synthesized in good chemical and optical yields by kinetic resolution of (±)-4-O-acetyl- (3) or (±)-4, 6-O, O-diacetylroemecarine (7) by the use of immobilized lipase OF-360 (Candida cylindracea) in organic solvents. (+)-Roemecarine (5) was proved to have 1S, 4S-configuration.
- 社団法人 日本薬学会の論文
社団法人 日本薬学会 | 論文
- Bioactive Constituents from Chinese Natural Medicines. XXXVI. Four New Acylated Phenylethanoid Oligoglycosides, Kankanosides J1, J2, K1, and K2, from Stems of Cistanche tubulosa
- Absolute Stereostructures of Olibanumols A, B, C, H, I, and J from Olibanum, Gum-Resin of Boswellia carterii, and Inhibitors of Nitric Oxide Production in Lipopolysaccharide-Activated Mouse Peritoneal Macrophages
- Medicinal Flowers. XXX. Eight New Glycosides, Everlastosides F—M, from the Flowers of Helichrysum arenarium
- Triterpenoid Saponins from the Stem Bark of Acanthopanax brachypus HARMS
- Mild Deprotection of Methylene Acetals in Combination with Trimethylsilyl Triflate–2,2′-Bipyridyl