The effect of the parenteral administration of chymotrypsin on emigration of the rat ascites hepatoma.:AH 66F, into the thoracic duct of rats
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In order to examine whether parenteral admi nistration of Chymotrypsin has stimulatory effects on emigration of the tumor cells into the vessels or not, a model experiment was carried out. The tumor cells used was a kind of rat ascites hepa toma, AH66F, with the prominent invasiveness and metastatic property which was inoculated into the mesentery of rats. And frequency in emig ration of the tumor cells into the thoracic duct was checked up by detecting morphologically the tumor cells in the lymph-fluid of the thoracic duct which were obtained by the operative cannu lation 5 days after inoculation of the tumor cells.<BR>Under these conditions, the effect of Chymot rypsin examined, and the following results were obtained:<BR>1) Massive parenteral administrations of Chy motrypsin were found not to accelerate both emigration of the tumor cells into thoracic duct and its proliferation at the site of the mesentery.<BR>2) In this experiment, the frequencies of dete ction of the tumor cells in the lymph-fluid of the thoracic duct were found only to be related with the size of the inoculated mesenterial tumor.<BR>These results suggest that, when Chymotrypsin are parenterally used to accelerate expectration of the sputum for the cytodiagnosis, it does not necessitate to be afraid of the stimulatory effects of Chymotrypsin on the metastasis of cancer cells in the clinical cases.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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