Significant factors influencing the accuracy of PTCD bile cytology for bile duct lesions.
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概要
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To identify some significant factors influencing the cytologic diagnostic accuracy of bile obtained through percutaneous transhepatic cholangiography drainage (PTCD), we retrospectively reviewed a series of 2957 specimens from 509 patients. We also evaluated the correlation between the cytologic diagnostic accuracy of PTCD-obtained bile and pathological factors including locations, and both gross and histological types of the lesions, in 101 patients who had undergone surgical resection of bile duct carcinoma.<BR>1. The overall sensitivity and specificity of PTCDobtained cytologic specimens were 66.9% and 96.8%, respectively. The sensitivity of the PTCD-obtained cytologic specimens in patients with surgically resected extrahepatic bile duct carcinoma was 80.0%.<BR>2. Increasing numbers of cytologic specimens correlated strongly with a higher rate of positivity although the frequency of cytologic examinations is not the only factor influencing diagnostic accuracy.<BR>3. Numbers of specimens examined in false negative cases tends to be fewer than those in positive cases.<BR>4. The positive ratio per examination was 28.8% in cancer-bearing patients.<BR>5. Lower sensitivity was observed in cytologic specimens from patients with carcinomas of the papilla of Vater.<BR>6. The diagnostic accuracy in patients with poorly differentiated carcinomas was higher than that in patients with well differentiated carcinomas.<BR>7. The diagnostic accuracy of PTCD-obtained bile did not correlate with tumor sizes.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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