Endometrial cytology of renal cell carcinoma metastatic to the uterus-A case report-:A case report
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<B><I>Background</I>:</B> Renal cell carcinoma metastasis to the uterus is extremely rare, and must be differentially diagnosed from primary endometrial clear cell cartinoma. We report a case of renal cell cartinoma metastasizing to the uterus.<BR><B><I>Case</I>:</B> A 62-year-old woman, 1G1P, who underwent surgery for renal cell carcinoma composed of clear cell carcinoma and granular cell carcinoma 11 months earlier, reported atypical genital bleeding. Endometrial cytology showed (1) clear hemorrhagic background, (2) normal atrophic endometrial cells, (3) atypical cells scattered or with irregular aggregation, (4) atypicalcells with abundant and granular cytoplasm and apparent cellularborder, and (5) enlarged nuclei with fine granular chromatinand 1 or 2 apparent nucleoli. Based on these findings, including granular cytoplasm and clear back ground, and a history of renal cell carcinoma, this case was diagnosed cytologically as metastatic renal cell carcinoma. In the resected uterus, granular cell carcinoma widely invaded the myometrium and the endometrium was normal atrophic. Tumor cells were immunohistochemically positive for CD10. These findings proved renal cell carcinoma metastatic to the uterus.<BR><B><I>Conclusion</I>:</B> For differential diagnosis of metastatic renal cell carcinoma and primary clear cell carcinoma of the uterusmimicking clear cell carcinoma, cytoplasmic findings of malignant cells must be considered in addition to clinical history. Immunohistochemical examination of CD10 is also useful.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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