A case of Merkel cell carcinoma on the upper eyelid. Significance of CK20 on the diagnosis of Merkel cell carcinoma in cytology.:Significance of CK 20 on the diagnosis of Merkel cell carcinorna in cytology
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<I>Background</I>: Markel-cell carcinoma is rare and its differential diagnosis is difficult by routine stain in cytology. We report significance of CK 20 on the diagnosis of Merkelcell carcinoma in cytology.<BR><I>Case</I>: We report a 74-year-old female farmer with Merkel-cell carcinoma on the right upper eyelid. On stamp preparation of the operated specimen tumor cells cytologically showed monotonous, relatively small round nuclei. These cells had an increased N/C ratio with scanty clear cytoplasms and oval nuclei with fine granular, reticular chromatin, and a few small nucleoli, but no cytoplasmic button-like globules. On smear preparation of fine needle aspiration from the neck tumor, tumor cells formed in Indian file, partly scattered individually, and showed uneven, large to small nuclei with mitotic figures. Histologically, monotonous small round cells infiltrated solidly into the cutis and were negative for PAS reaction and reticulin silver impregnation. Immunohistohemically, tumor cells were diffusely and strongly positive for cytokeratin (CK 20, AE1), NSE, Chromogranin A, EMA, and partially positive for neurofilament, synaptophysin, but negative for S 100-P, vimentin, cytokeratin (AE3), CEA, LCA, and HMB 45. Electronmicroscopy indicated that these cells had a small number of neurosecretary granules, paranuclear intermediate filaments, and desmosome-like structures.<BR><B><I>Conclusion</I>:</B> In differential diagnosis of three cases of Merkel-cell carcinoma and 8 types of other carcinomas, only Merkel-cell carcinoma was diffusely and strongly positive for CK 20. So, diffuse positivity of CK 20 is a significant finding in diagnosis of Merkel-cell carcinoma by cytology.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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