Cytological endometorial heperplasia with new classification. Cytological features of endometrial hyperplasia and grade 1 endometrioid adenocarcinoma. With emphasis on morphologically abnormal cell clumps.:With emphasis on morphologically abnormal cell cl
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<B><I>Objective</I>:</B> The objective of this study was to establish cytological criteria for the diagnosis of endometrial hyperplasia and grade 1 endometrioid adenocarcinoma.<BR><B><I>Study Design</I>:</B> The incidence of each of 12 morphological types (8 morphological types of cell clumps reflecting tissue architecture and 4 types reflecting cell atypism) was examined in 11 cases of simple endometrial hyperplasia, 31 cases of complex endometrial hyperplasia, 10 cases of atypical hyperplasia, 38 cases of grade 1 endometrioid adenocarcinoma, and 35 individuals with normal endometrium.<BR><B><I>Results</I>:</B> 1. If the percentage of abnormal cell clumps is over 20%, endometrial hyperplasia or more severe disease is suspected. If the percentage is over 70%, atypical hypertilasia or more severe disease is suspected.<BR>2. Simple endometrial hyperplasia is suspected in cases where clumps of dilated glands (with a maximum width more than twice the minimum width) are predominant.<BR>3. Complex endometrial hyperplasia or more severe diseases are suspected in cases where irregular protruding clumps, papillary clumps, clumps with high densities of glands, or dendriform clumps are predominant.<BR>4. Dendriform clumps are a characteristic of grade 1 endomatrioid adenocarcinoma. Thus, the presence of dendriform clumps with two or more bifurcations strongly suggests grade 1 endometrioid adenocarcinoma.<BR>5. Small clumps of atypical cells and the presence of necrotic background suggest grade 1 endometrioid adenocar-cinoma. Uptake of inflammatory cells and squamous metaplasia of cells suggest atypical hyperplasia or more severe disease.<BR>6. Swelling or size irregularity of nuclei suggest atypical hyperplasia or more severe disease.<BR><B><I>Conclusion</I>:</B> Evaluation of specific morphological types of cell clumps, reflecting tissue architecture, is essential when making a diagnosis of endometrial hyperplasia or grade 1 endometrioid adenocarcinoma.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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