Clinical significance of bizarre stripped nucleus in human papilloma virus infection.
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We studied the appearance of a "bizarre stripped nucleus (BSN) ", with cytomorphological and immunocytochemical methods, in cervical smears from cervical dysplasia with human papilloma virus (HPV) infection.<BR>Cases with HPV infection were classified as Group I (appearance of BSN in four cases) and Group II (nonappearance of BSN in 25 cases). We analyzed BSN in terms of cytomorphological features, origin, and the correlations with the existence of koilocytes and HPV capsid antigen.<BR>(1) Among the cytomorphological features of BSN, the stripped-nucleus lacks cytoplasm and shows bizarre nuclear forms of lobulation or multinucleation. The chromatin is reticulated and has a smudged structure with coarsely clumped chromatin. No nucleolei were seen.<BR>(2) Of 24 BSNs, HPV capsid antigen was detected in 23 (95.8%).<BR>(3) Koilocytes were detected in one of four cases (25%) in Group I and in six of 25 cases (24%) in Grup II.<BR>(4) Among dyskaryotic cells, HPV capsid antigen was detected in 314 of 910 (34.5%) in Group I and 368 of 4374 (8.4%) in Group II.<BR>(5) It was considered that the origin of BSN is over-proliferation of HPV.<BR>(6) In BSN, the form was considered to be virion type.<BR>We suggest, based on these new cytomorphological findings, that the appearance of BSN indicates HPV infection involving numerous virions.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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