A case of ovarian mixed germ cell tumor with ascites.
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A case of ovarian mixed germ cell tumor, which was composed of immature teratoma, yolk sac tumor and choriocarcinoma and studied histopathologically, immunohistochemically and ultrastructually, is reported. The patient was a 19-year-old female with abnormal genital bleeding and a rapidly growing tumor in the right lower abdominal region. An ultrasonogram and a computed tomographic (CT) scan showed a solid mass in the upper right area of the uterus, and some ascites. Serum α-fetoprotein (AFP), CA-125 and human chorionic gonadotropin (hCG) levels were elevated. Cytologically, the ascitic flivid revealed some neoplastic cells againsts background of histiocytes, mesothelial cells and red blood cells. The neoplastic cells were relativesly large, their cytoplasm was lacy, and their cell borders were indistinct. Their nuclei were round-oval shaped and hyperchromatic, and the nucleoli were large and prominent. Cytologically, these cells resembled immature nerve cells in immature teratomas. Histologically, the neoplasm consisted not only of immature nerve cells (Grade III), but of various differentiated tissues, including intestine, squamous epithelium, bronchus, and thyroid. Immunohistochemical examination of a small portion of the specimen showed hCG-and AFP-positive cells, and the neoplasm was diagnosed as a mixed germ cell tumor. The-electron-microscopic findings matched the characteristics of immature nerve cells.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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