A case of human parvovirus B19 infection associated with hydrops fetalis.

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The cytologic findings of a case of hydrops fetalis (fetal age 25 weeks) infected with human parvovirus B 19 (B 19) were studied in body fluids at autopsy. The diagnosis of B 19 infection was established by the immunoperoxidase method and polymerase chain reaction (PCR).<BR>During an endemic outbreak of erythema infection in 1991 in Kanagawa prefecture, Japan, a 28-year-old woman at 10 weeks of gestation acquired a mild rash on her face accompanied by slight fever and arthralgia. At 25 weeks and 2 days of gestation, the fetus died of hydrops fetalis and pregnancy was terminated.<BR>At autopsy intranuclear inclusions were not clearly observed on ascitic fluid cytology using bluish-purple papanicolaou staining. But these infected cells were well demonstrated by the immunoperoxidase method and PCR. In paraffin-embedded tissue of the lung, heart, liver, spleen, kidney, stomach, and placenta at autopsy, the intranuclear inclusions were observed. In these cells, the B 19 antigen was also detected in cytoplasm by the immunoperoxidase method (indirect).<BR>It is suggested that recognition of B 19 infected cells in body fluids is a useful method of diagnosing hydrops fetalis due to B 19 infection during pregnancy.
特定非営利活動法人日本臨床細胞学会の論文