Clear cell carcinoma of the uterine corpus following irradiation therapy for squamous cell carcinoma of the cervix: a case report.
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A case of clear cell carcinoma of the endometrium following squamous cell carcinoma of the cervix is reported.<BR>The patient had had a previous cervical biopsy which revealed squamous cell carcinoma (large cell non-keratinizing type), classified clinically as a stage fib lesion. She was treated with external pelvic irradiation delivering an estimated tumor dose of approximately 7, 000 rads and intracavital radium application delivering 4, 995 mg. hr. radiation when she was 51 years old. She complained of postmenopausal bleeding at age 66 and was diagnosed by endometrial cytology as having clear cell carcinoma of the endometrium. Total abdominal hysterectomy, bilateral salpingo-oophorectomy and omentectomy were performed. The clinical stage of the endometrial cancer was lb, She is alive after 2 years with no evidence of disease.<BR>Endometrial cytology revealed several adenocarcinoma cells in small clusters. The shape of the nuclei was somewhat irregular, the chromatin pattern was fine granular, and single or multiple nucleoli were seen. The diameter of these nuclei ranged from 10 to 30μm. The cytoplasm was pale green or vacuolated. The volume of the cytoplasm varied from scanty to abundant. These findings suggested clear cell carcinoma.<BR>Histopathologically, an irregular shaped polypoid tumor, 3×1.5 cm in size, was located on the lower anterior wall of the uterine corpus. The tumor was a clear cell carcinoma showing a solid and papillary pattern. A hobnail pattern was not observed. The cytoplasm was clear and abundant, and PAS-positive granules digestible by diastase were seen.<BR>These 2 cancers had different pathological features and their immunohistochemical reactivities for CEA and keratin were also different. This patient was regarded as having a rare heterochronous double cancer consisting of squamous cell carcinoma of the cervix and clear cell carcinoma of the endometrium.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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