Breast carcinoma associated with osteoclast-like giant cells. clinical and cyto-pathological studies of eleven cases.:clinical and cyto-pathological studies of eleven cases
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Fifteen cases of breast carcinoma with osteoclast-like giant cells (OCGC) were analyzed clinico-cytopathologically. Cytological and pathological specimens were obtained from young and elderly women with a mean age of 45.6 years. The specimens from 11 cases obtained by preoperative aspiration biopsy cytology were moderately cellular with mild inflammatory cells and blood. Necrotic debris was scarce. There was a dimorphic pattern of cells a large number of cancer cells and scattered OCGC. The cancer cells overlapped, forming clusters with dyshesiveness. They possessed ill-defined cytoplasm and irregularly-contoured round nuclei with hyperchromatism and mild anisonucleosis. OCGC, varying from 30 to 180 pm in size, had abundant well-delineated cytoplasm in which up to 80 central, vesicular nuclei with a few prominent nucleoli were present. Macroscopically, the tumor, measuring less than 2 cm in nine cases, was a well-demarcated, dark brown mass. Histological examination revealed an invasive ductal carcinoma showing tubular, solid and scirrhous growth, and reaching the extramammary adipose tissue in 12 cases. OCGC were observed among the tumor cell nests associated with a marked increase in capillaries. In immunohistochemical examinations, KP-1, an excellent marker for monocyte/macraphages, was positive in 75% of the cases examined. One patient died of the disease 4 years and 8 months after surgery and signs of recurrence are evident in another case.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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