Cytological features of an epithelioid osteosarcoma-case report.
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Epithelioid osteosarcoma of the right femur in a 17-yearold Japanese male was reported.<BR>Cytological examinations with imprinted specimens from the intra-and extra-osseous tumors revealed clusters of polyhedral cells with round nuclei and pleomorphic cells with round to fusiform nuclei. Multinucleated bizarre giant cells were also scattered. Neither osteoid nor allied substances were observed.<BR>The clustered epithelioid cells with round nuclei were not initially interpreted as osteosarcoma cells but as epithelial tumor cells. Histochemically, both types of tumor cells showed strong positivity for alkaline phosphatase. Histologically, the tumor mass was composed of a nest of polyhedral tumor cells with fine fibrovascular stroma without osteoid structures. However, because the lacelike osteoids closely associating with round and fusiform tumor cells were observed, a final diagnosis of osteosarcoma was given.<BR>This case suggests that cytological diagnosis of osteosarcoma should be based upon a combination of complete clinical data and enzyme histochemical examinations.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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