Endodermal sinus tumor of the vagina: A case report with cytologic, immunohistochemical and ultrastructural studies.:immunohistochemical and ultrastructural studies
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概要
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A rare case of endodermal sinus tumor of the vagina is reported. The patient, a 9-month-old female, was admitted to the hospital with a chief complaint of vaginal bleeding. A vaginal tumor was found and was discharged spontaneously.<BR>Imprint smears of this tumor revealed pleomorphic malignant cells occurring in irregular or sheet-like clusters with ill-defined cytoplasmic borders. PAS-positive hyaline globules were seen in and around the tumor cells. These findings suggested a diagnosis of endodermal sinus tumor. Histologic examination revealed the typical reticular or microcystic pattern of endodermal sinus tumor with Schiller-Duval bodies and hyaline globules. Immunohistochemically, there was a positive reaction for AFP in the cytoplasm of the tumor cells. Positively stained globules were also identified. Ultrastructurally, small acinar lumina surrounded by tumor cells with microvilli, desmosome junctions and electron-dense basement membrane material were noted.<BR>Most malignant tumors of the vagina in infants and children are rhabdomyosarcomas, but endodermal sinus tumor and clear cell carcinoma are seen rarely. Imprint smears appear to be useful in the differential diagnosis of these tumors.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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