Cytological and immunocytochemical study of chordoma.
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概要
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Imprint smears were obtained from two chordomas which developed in the sacrum of an 8-year-old male and in the coccyx of a 40-year-old female. Chordoma cells were examined morphologically and immunocytochemically.<BR>In both chordomas, there were three kinds of tumor cells: physalipherous, stellate, and intermediate cells. With respect to their immunocytochemical characteristics, all three types contained EMA, cytokeratin and keratin, markers indicating epithelial cell origin. Moreover, they all were positive for S-100 protein, NSE and vimentin, markers indicating non-epithelial cell origin. Stellate cells and intermediate cells were CEA-positive, but physalipherous cells were not.<BR>These results indicate that the three kinds of tumor cells composing chordomas may be of the same lineage, although they are morphologically different.<BR>Furthermore, it was thought that immunocytochemical evaluation was useful in the cytological diagnosis of chordoma, because chordoma cells have characteristics of both epithelial cells and non-epithelial cells.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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