Eosinophilic pericarditis with atypical plasma cells in PIE syndrome.
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A case of eosinophilic pericarditis with atypical plasma cells in pulmonary infiltration with eosinophilia (PIE) syndrome was reported.<BR>A 61 year-old man with recurrent asthma in recent years admitted to the hospital because of dyspnea and fever. Diffuse pulmonary infiltrations appeared in the lower lobe of the left lung with a blood leukocyte count of 17, 000 per cu, mm., 20 percent eosinophil content (PIE syndrome). The sputum contained numerous eosinophils but significant bacterial pathogens. After treatment with prednisolone, his symptoms and signs of the disease disappeared promptly and clinical data returned to normal. On the 10 days after his discharge, he readmitted to the hospital because of progressive dyspnea and chest discomfort. A chest roentgenogram showed mediastinal enlargement of the cardiac shadow and cardiac echogram revealed pericardial fluid. Pericardiocentesis was performed and 200 ml of a yellow fluid were removed.<BR>Smears of the sediment of the pericardial effusions showed numerous eosinophils (69%), lymphocytes, histiocytic cells and atypical plasma cells with irregular and multiple nuclei, predominant nucleoli and frequent mitotic figures. However, physical and laboratory data, including bone marrow aspiration etc. did not reveal any malignancy. He rapidly improved after therapy with prednisolone and is apparently well.<BR>It has been suggested that pleomorphism of plasma cells in the pericardial effusions may be regarded as benign reactive atypia.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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