Immunocytochemical localization of Transferrin Receptor of exfoliated cells in gynecologic cytology.
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概要
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This study was performed to identify transferrin receptors of exfoliated cells in gynecologic cytology using monoclonal antibody (anti OKT9 antibody) and the immunoperoxidasetechnique (ABC method). In normal villi, syncytio-trophoblasts showed positive staining but, cytotrophoblasts showed negative staining.<BR>In normal cervical epithelium, though basal cells showed negative staining, parabasal cells were positive. However intermediate and superficial cells were negative for OKT9.<BR>When the epithelium was dysplastic, basal cells showed positive staining. For example, in mild dysplasia basal, parabasal cells and part of the intermediate cells were positive. In CIS, cancer cells were positive. With respect to invasive cervical cancers, both squamous cell cancer cells and adenocarcinoma cells showed strongly positive staining, but the stroma stained negatively. Therefore there was a clear distinction between the stroma and the cancerous lesion.<BR>Endometrial cancer showed strongly positive staining.<BR>The anti-transferrin receptor antibody used in this study provided a useful additional method for the diagnosis of gynecological malignancies.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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