Immunocytochemical localization of GFA protein in imprint smears of human brain tumors.
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The presence and distribution of glial fibrillary acidic (GFA) protein in imprint smears were studied in 38 human brain tumors, using the peroxidase-anti-peroxidase method. The materials included 7 astrocytomas, 5 anaplastic astrocytomas, 12 glioblastomas, 1 mixed astrocytoma and oligodendroglioma (mixed glioma), 2 ependymomas, 5 medulloblastomas, 3 meningiomas and 3 metastatic adenocarcinomas from the lung. For comparison, 3 specimens of cerebral white matter taken from autopsy cases without neurological diseases were also investigated.<BR>In normal cerebrum, only the cell processes and perikarya of fibrillary astrocytes were stained. In astrocytomas, anaplastic astrocytomas and glioblastomas, all tumors studied were positive for GFA protein. In these cases, a distinct negative correlation existed between the degree of anaplasia and the intensity of immunostaining.<BR>The positive reaction was also observed in 2 ependymomas and astrocytic elements of mixed glioma. In medulloblastomas, only one tumor contained a few cells with a positive staining reaction for GFA protein in their scanty cytoplasm and slender processes. The tumor cells in meningiomas and metastatic adenocarcinomas were invariably negative.<BR>These results suggest that demonstration of the GFA protein is helpful in cytodiagnosis of brain tumors.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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