A case suspected of polyoma virus infection by urine cytology.
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We experienced a case suspected of polyoma virus infection, recognizing extremely varied intranuclear inclusionsin the urine of a five-year-old girl under the treatmend for acute renal insufficiency. The nuclei of intranuclear inclusions swelled quasicircularly to a diameter of 11 to 18 microns. Irregular chromatin blocks deposited on the nuclear membrane. The cytoplasm was vesicular, suggesting a strong tendency of degeneration, and many nuclei were oddly shaped or bare in a disintegrated dropout state. The intranuclear inclusions exhibited a deep bluish green ground-glass appearance, and the cells could be roughly classified into types I, II, III, and III' based on their characteristic appearances.<BR>Type I refers to cells appearing opaque like ground glass having a relatively well preserved cytoplasm, in which a large single intranuclear inclusion occupied the whole inside of nucleus.<BR>Type II refers to cells having a lot of relatively small inclusions, in a oval, or irregular form.<BR>Type III refers to cells having a large single inclusion in a circular or quasicircular form measuring 8 to 11 microns in diameter with "bird eye" or "owl eye" halo between the periphery and nucleus.<BR>Type III' refers to cells showing a large single inclusion similar to those of type III by low-power magnification, but this indusion was revealed to be conoisted of several small inclusions by high-power magnification.<BR>Intranuclear inclusions of two nuclei were also noted.<BR>Chronologically, most intranuclear inclusions deteced in the urine may belong to type I initially, but the incidence of this type gradually decreased later on while types II, III, III' increased.<BR>Considering the varied forms of intranuclear inclusions, it was estimated from the findings with light microscope and electron microscope that the viral particles in the type I nuclei cyrstallized with time lapse and reduced in volume to produce an open space in the nuclei, eventuall progressing to types II, III'.<BR>The duration of appearance of intranuclear inclusions was about a week, and no change was found in the clinical symptoms.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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