Micro-Spectrophotometric Nuclear DNA Analysis of Aspirated Cells from Thyroid Tumor
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Cytological differentiation by aspiration biopsy between benign adenoma and carcinoma of thyroid is difficult morphologically. We investigated the utility of micro-spectrophotometric measurement of nuclear DNA contents in differential diagnosis of these diseases. Of 24 cases, 6 cases were histologically diagnosed to have carcinoma, 8 cases, benign adenoma, 6 cases, thyroditis and 4 cases, cystic formation.<BR>Nuclear Feulgen-DNA contents were measured with multi-micro-spectrophotometer (Olympus) at wave length of 550nm.<BR>The nuclear Feulgen-DNA contents of all benign cases (adenoma, thyroiditis and cyst) were distributed mainly in diploid area, except one case of benign adenoma (follicular adenoma) showing increased nuclear DNA contents.<BR>The nuclear Feulgen-DNA contents of carcinoma cases showed DNA histogram pattern, and major peaks of all cases were observed beyond 3 C region.From this study, it is concluded that micro-spectrophotometric measurement of nuclear DNA contents of aspirated cells could be helpful to differentiate benign nature from malignant one in patients with thyroid involvement.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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