Cytodiagnosis of Primary Carcinoma of the Liver
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概要
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The utility and reliability of aspiration biopsy were proved in the cytodiagnosis of liver tumors. A retrospective analysis was made for 157 cytologic specimens (144 of fine-needle aspirates and 13 of touch preparations from the livr) taken at the Cytodiagnostic Unit of the Central Laboratory in the Nagasaki University Hospital, during the period from 1970 to 1979. The series comprised 35 cases with liver cell carcinoma (hepatoma), one with hepatoblastoma, six with cholangioma, 47 with metastatic carcinoma, three of malignant lymphoma, 19 with liver cirrhosis and 28 with others lesions.The cases whose slides showed neither liver cells nor tumor cells and whose diagnoses were established neither clinically nor histologically, were excluded f rom this study.<BR>Out of 35 cases with liver cell carcinoma, 30 cases were cytologically diagnosed as hepatoma, four were suspected of malignancy and one was negative. Cholangioma was confirmed only in one out of six cases; one was negative and the remaining cases had hepatoma or metastatic carcinoma. Of the 47 cases with metastatic carcinoma, 42 were positive, however, the determination of the origin of the tumor was difficult. A false positive was f ound among the 19 cases with liver cirrhosis.A cytologic diagnosis of malignant tumor was made in 80 cases (87%) out of the 92 cases.<BR>The cytomorphologic features of hepatoma were as follows; 1) the presence of well-developed, granular and ill-defined cytoplasm, 2) variation in nuclear size with giant nuclei (anisonucleosis), 3) enlarged nucleoli, 4) intracytoplasmic bile pigment, 5) eosinophilic cytoplasmic inclusions. The N/C ratio was small.As either cholangioma or metastatic carcinoma of the liver demonstrated no morphological details contributing these diagnoses, it's difficult to give a specific diagnosis just based on the cytological criteria alone. A cytological preparation from liver cirrhosis revealed a picture of benign proliferative hepatic cells resembling that of hepatoma.Consequently, difficulty arose in differentiation of cirrhosis f rom carcinoma. The cytomorphological differentiation of primary live carcinoma could be of especial importance from two points of view. It is well-known that carcinoma of the liver most often occurs in cirrhotic liver. Today, surgical treatment is technically possible in some cases. The study herein reported demonstrated the value of fine-needle aspiration biopsy of the liver for the cytological diagnosis of liver tumors.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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