Patients with Calcinosis Cutis in National Leprosarium Matsuoka Hoyo-En

概要

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As of the year 1991 there were 358 leprosy pa-tients in National Leprosarium Matsuoka Hoyo-En, including 223 patients (62.3%) who had received the injections of chaulmoogra oil before. Calcinosis cutis caused probably from the injections was noted on 73 patients (32.7%): 67 lepromatous and 6 tuberculosis cases. It has never been reported be-fore that the T type patient suffering from calcino-sis cutis was observed in the cases of the chaul-moogra oil injection in Japan.The detectable positions of calcinosis cutis were mostly at the injected sites, that is, outside the right brachium followed by bilateral-branchia and crura. In the group of patients with calcinosis cutis, the anti-PGL antibody was negative for the most part. Urinalyses, peripheral blood figure analyses, histopathological tissue examinations of calcium deposition, X-ray diffraction patterns, dif-ferential thermal and gravitational analyses, and chemical analyses were performed on all patients with this disease.Further, as the result of this study six patients with calcinosis cutis caused by sulpyrine was also found. The major component of the deposit by the drug was calcium phosphate.These calcinosis cutis were considered to be of trophopathic calcinosis based on the disorder of subcutaneous tissue due to the injections of respec-tive drugs : chaulmoogra oil and sulpyrine.
日本ハンセン病学会の論文