Peripheral Nerve Lesions of Experimental Leprosy in Monkeys:V. Histopathological Finding of Cutaneous Nerves and Cutaneous Sensory Organs
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The skin samples of each palm side and dorsum side of finger, nose and peripheral nerves running under the finger skin at the area between proximal phalanx and distal pha-lanx of mangabey monkey A022 and rhesus monkey A125 were studied by histopathologi-cal methods (semithin section and light microscopic findings).Results found about this study were as follows.1. In spite of the existance of a large amount of leprosy bacilli at the areas of corium and subcutis, some of Meissner's corpuscles, Vater-Pacinian corpuscles (or Golgi-Mazzoni's corpuscles) and Krauze's end bulbs-like structures were observed.2. Occasionally, several intracytoplasmic foamy structures containing a large amount of leprosy bacilli were observed at the shallow and deep layers of stratum papillare of cor-ium, where leprosy bacilli were not so remarkable as shown on Figure 4. So, it was thought that the affinity of leprosy bacilli to free nerve endings should be existant there.3. Some of M, arrector pili were kept in good condition in spite of the existence of multiplying leprosy bacilli around the hair follicles.4. It was thought that the histopathological findings of the fascicles of cutaneous nerves were classified to 4 patterns.The first pattern of histopathological finding of the cutaneous nerve was shown as A on Figure 25. In this pattern observed in almost of all the fascicles locating at the subcutis, no leprosy bacillus was observed inside the fascicles, and the nerve fibers were kept in good condition.The second pattern observed in almost of all the fascicles located at the corium, was shown as B on Figure 25. In this pattern, a large amount of leprosy bacilli were observed inside the fascicles, and the nerve fibers were often kept in good condition.The third pattern observed in almost of all the fascicles located at the deep layer of corium and subcutis, was shown as C on Figure 25. In this pattern, not only multiplying leprosy bacilli but also remarkable fibrosis were found inside one fascicle, and many nerve fibers disappeared by the existence of the bacilli and fibrosis.The final pattern observed in almost of all the fascicles located at the deep layer ofcorium and subcutis, was shown as D on Figure 25. In this pattern, remarkable fibrosis was observed inside the fascicles, and the nerve fibers often disappeared by the existence of fibrosis.5. Inside the fascicles of peripheral nerves running under the skins of palm side and dorsum side of fingers (N, digitaris palmaris proprii, ramus dorsalis N. ulnaris, N. uln-aris, N, digitaris palmaris radialis proprii, etc), a large amount of leprosy bacilli were observed, but the fibrosis was not so remarkable.6. Remarkable fibrosis was sometimes observed inside the small nerve fascicles runn-ing between the deep layer of subcutis and N. digitalis dorsalis proprii of little finger. And, some young myelinated nerve fibers were observed in spite of the existence of a large amount of intracytoplasmic foamy structures containing leprosy bacilli inside the fas-cicles of N, digitaris palmaris proprii running at middle phalanx of little finger.7. Many organs of Hoyer-Grosser were intact, but blood vessels of the organs were often obliterated. It was thought the histopathological finding of the organs caused to the ischemia of the skin.From these results, the problems of peripheral sensory nerve paralysis in leprosy, espe-cially "individual disturbance of sensibility" and "pattern of ripped gloves (or ripped so-cks, )" were discussed in this paper.
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