The Hereditarily Asplenic-Athymic (Lasat) Mouse as an Experimental Animal Model of Lepromatous Leprosy: Role of the Spleen in the Formation of Lepromatoid Lesions
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概要
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Hereditarily asplenic-athymic mice with the background of BALB/c, artificially splene-ctomized congenitally athymic mice of various strains and comparisons of susceptibility to M. leprae were made with control hereditarily athymic mice by inoculations made on the right intra-upper lip and right hind foot. Evidently hereditarily asplenic-athymic mice and artificially splenectomized congenitally athymic mice showed higher susceptibility than the respective control. In addition, difference in the susceptibility to M. leprae was observed among strains of splenectomized congenitally athymic mice, the congenitally athymic mice strains with backgrounds of NFS/N, C3H/HeN+MTV and CBA/N previously reported were found to demonstrate further enhancement of their susceptibility to M. leprae following splenectomy. Multiplication of M. leprae in severely deformed hind foot was not detected with congenitally asplenic mice. But, in the case of hereditarily asplenic-athymic mice which were observed to have highly advanced deformities of the femur and tibia with muscular atrophy, though the macroscopic swelling of the inoculated hind foot appeared to depressed, the proliferation of M. leprae reached to the bone-marrow at the later stage of inoculation. Further, regarding hereditarily asplenic-athymic mice, aside from the individual difference accompanying the difference in the grade of hind limb deformity, tumor formation and aging also influenced the M. leprae susceptibility. In conclusion, this study is suggested that the M. leprae susceptibility would still be enhanced, if new hereditarily asplenic-athymic mice of milder hind limb deformity are produced by mating the congenitally athymic mice of high susceptibility to M. leprae and the hereditarily asplenic mice.
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