Ultracytochemical and Light Microscopic Histochemical Studies in Murine Leprosy
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概要
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The present study was carried out to envisage lysosomal status and mechanisms involved in the two polar types of murine leprosy using different strains of mice. Suspensions of 1×107M. lepraemurium of Hawaiial strain was injected subcutaneously into the sternal area of specific pathogen free (SPF) male mice of following strains: C57BL/6N, CBA/J, C57BL/6N (nu/+), and C57BL/6N (nu/nu). acid phosphatase and alkaline phosphatase were demonstrated using coupling azo-dye methods. Lysosomes were demonstrated at ultracytochemical level using acid phosphatase as marker enzyme. The present study revealed that the lysosomal morphology and functional behaviour in immunologically activated macrophages in resistant strains of mice was almost similar to the observations discerned in tuberculoid leprosy where cell mediated immunity is present. The other polar type of murine leprosy in immunologically deficient strains of mice revealed that lysosomal morphology and its cell membrane integrity was lost, which is also observed in human lepromatous leprosy which is devoid of cell med- iated immunity.
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