Plasma Levels of DDS in Leprosy Patiets Admitted in The National Sanatorium Oshima Seisho-en
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概要
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Plasma levels of DDS in 40 leprosy patients, who were admitted in the Natioaal Sanatorium, Oshima Seisho-en, were studied by means of gas chromatography.These leprosy patients having some complications and 2 healthy adults as the control were given dietary DDS of 75 mg or 50 mg in the morning. The gas chromatographic analysis of plasma level of DDS were performed at 5 or 2 hours before (single bleeding) and after (bleeding, once or 4 times) medication with DDS.1) Plasma levels of DDS in the leprosy patients were positive after 24 hours of DDS medication.2) Plasma levels of DDS were high in the leprosy patients complicated by renal disease (chronic gromerulonephritis pyelonephritis).3) Plasma levels of DDS were low in the leprosy patients complicated by degestive disease (gastritis, gastric ulcer and duodenal ulcer).4) Patterns of plasma levels of DDS in the leprosy patients complicated by liver disease (hepatitls) and circulatory disease (hypertension and asthma cardiale) were very similar to those of controls.
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