Susceptibility to Mycobacterium avium of Various Inbred Strains of Mice:IV. Comparative Observations on Virulence of four Strains of M, avium

概要

論文の詳細を見る
Comparative observations were made on the virulence of four strains of M. avium, Kirchberg, Nagoya #59, Flamingo and ATCC 19075, in five inbred strains of mice, C 3H, C 57 BL/6, DDD, BALB/c and KK. The virulence was evaluated by the average survival time and also by the grade of visceral lesions following intraperitoneal infection with 0.5mg and subcutaneous infection with 0.025mg of 14 day-culture of M. avium grown on 1% Ogawa's medium, as described in Parts 1 and 2 of this report.Following the intraperitoneal infection, two strains, Kirchberg and Nagoya #59, were highly pathogenic for four strains of mice, C 57 BL/6, DDD, BALB/c and KK, causing a more severe infection than the others. Strain Flamingo was pathogenic for three strains, C 57 BL/6, BALB/c and KK, but slightly pathogenic for DDD strain. In contrast, in all the mice infected with ATCC 19075, only a few bacillus-containing cells were occasionally detected from their visceral organs even at 50 weeks, the end of this experiment. It is noted that C3H mice were very resistant to the infection with all the strains of M. avium tested, throughout the observation period.The similar tendencies on the pathogenicity of M, avium were also demonstrated in the cases with subcutaneous infection.The results of these experiments revealed that Kirchberg and Nagoya 59 were highly virulent, Flamingo was moderately virulent and ATCC 19075 was low virulent.
日本ハンセン病学会の論文