Susceptibility to Mycobacterium avium of Various Inbred Strains of Mice:III. On the Cases Intraperitoneally Infected with Small Dose
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概要
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Male mice, approximately 6 weeks of age, of 6 inbred strains (C 3 H, C57BL/6, DDD, BALB/c, KK and CF#1) were inoculated intraperitoneally with 0.005mg of M. avium, strain Kirchberg. Susceptibility to M. avium was evaluated mainly by the average survival time and visceral lesions of experimental animals.C3H strain mice were confirmed to be resistant to the infection with M. avium. And mice of the other strains were susceptible. However, there was remarkable difference in average survival time beween KK and CF#1 group and C57BL/6, DDD and BALB/c group.From the results of our earlier experiments with mouse leprosy, above mentioned difference in the susceptibility was assumed to be due to cell-mediated immunity developed in the hosts, excepting C 3 H strain.
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