Susceptibility to Mycobacterium avium of Various Inbred Strains of Mice:1) On the Cases with Intraperitoneal Infection
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概要
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Comparative observations were made of the susceptibility of various inbred mouse strains (C3H, C57BL/6, DDD, BALB/c and KK) to intraperitoneal infection with avian tubercle bacilli, strain Kirchberg, concerning development of their visceral lesions, multiplication of the bacilli in the visceral organs and mean survival time of the infected mice.Following intraperitoneal infection, the visceral lesions developed early in the KK strain and became so severe as to cause the ultimate death of the host, while in the C3H strain, the visceral lesions developed more slowly and remained still slight at the late stage of infection. The development of visceral lesions in the other strains was intermediate to that observed in these two, but much closer to the KK strain.These mouse strain differences in the susceptibility are assumed to be mainly due to multiplication rate of the bacilli in the host.
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