Influences of Several Antileprosy Drugs on Immunological State of Experimental Animals

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Influences of DDS and B663 on immunological state of mice and guinea pigs were examined. The influence on humoral immunity was examined by an improved Cunningham plapue forming method and that on CMI by both of delayed-type hypersensitivity test and the rosette formation between guinea pig lymphocytes and rabbit red blood cells.The results found were:1. DDS showed no influence on humoral immunity but decreased strongly T cell rosette per cent, especially in thymectomized guinea pigs.2. B663 weakly suppressed humoral immunity but strongly increased T cell rosette per cent of those which were beforehand immunodepressed by both of dosing DDS and thymectomy.3. Levamizole as a standard drug potentiated both of humoral and CMI.4. The in vivo remaining of B663 could resist against the artificial immunodepression by thymectomy, thus could avoid the lowering in T cell rosette per cent.5. Since the in vitro influence of DDS on the rosette per cent could not be detected and that of B663 was found to be slight, the in vivo influences of DDS and B663 were supposed to be not caused by the direct actions of them on guinea pig lymphocytes.6. Standing on these results, the mechanisms of actions of DDS and B663, especially the ocurrence mechanism of DDS resistant patients were discussed by immunological view.
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