Experimental Transmission of M. leprae in Mice Treated with Anti-lymphocyte Serum

概要

論文の詳細を見る
Anti-mouse (C3H/He) ALS was used severally for immunosuppressing four different strains (C3H/He, IH-F, IB-F & ddy) of mice, and then leprosy bacilli taken from lepromatous patients were inoculated into their testes.When the strain of mice was the same as in the ALS (C3H/He), they lived less than 6 months after the leprosy bacilli inoculation. Despite this, they lived for a long times on the skin graft transplantation (3, 4). That is, these ALS treated mice might be more wasting to these bacterial infection than the skin transplantation tests.The positive data in the present examination were that the acidfast bacilli were found to be abundant intracellularly, as globi (+G). The effects of C3H/He-ALS were different as far as their mouse strains are concerned : The ddy mice injected with ALS and infected with leprosy bacilli had an antipodal reaction to that of C3H/He mice. However, both C3H/He and ddy mice were negative to infection (+G) of leprosy bacilli. In the hybrid mice, IH-F mice originated from C3H/He were similarly reactive to ALS and leprosy infection to C3H/He mice, and 7B-F mice orginated from C37BL/6 survived for 8 months longer than the C3H/He groups, and many AFB-loaded cells were observed in these testes.
日本ハンセン病学会の論文