Studies on the quantitative structure activity relationship of antimutagenic phenol carboxylic acids to benzo(a)pyrene.
スポンサーリンク
概要
- 論文の詳細を見る
Quantitative structure-activity relationship was studied on antimutagenic phenol carboxylic acids. Antimutagenic activities of 117 compounds were examined with Ames test by using Salmonella typhimurium TA98 with S9 mix. Benzo[a]pyrene was used as a reference mutagenic substance. Seven compounds which were hardly soluble in the test medium and six compounds which showed a killing effect were omitted in the evaluation of antimutagenicity. Theory of quantification I was applied to this study. The chemical structures of the above 104 compounds were classified into 3 items : principal structure, substituent groups, and the functional groups of side chain. The results between the range of standardized categorical weight and partial coefficient did not coincide. As the categorical weight of phenols was so great, that 10 phenols compounds were omitted, and then recalculated. It was found that φR (1) OH (3, 4, 5), coumarin, φR (1) OCH<SUB>3</SUB> (3, 4, 5), and φR (1) OH (2, 4, 6) acted for enhancing antimutagenicity, while φR (1) CHO (4), φR (1) COOH (2), and φR (1) COOH (4) acted for enhancing mutagenicity. The regression line of structure-antimutagenic activity lied in Y=0.62X+9.15. (The following symbols are used : X, Y ; observed and calculated values of antimutagenic activity, respectively, φ ; benzene ring, R ; side chain, and the numbers in parentheses ; the numbers of position for substituent groups)
- 社団法人 日本薬学会の論文
社団法人 日本薬学会 | 論文
- Bioactive Constituents from Chinese Natural Medicines. XXXVI. Four New Acylated Phenylethanoid Oligoglycosides, Kankanosides J1, J2, K1, and K2, from Stems of Cistanche tubulosa
- Absolute Stereostructures of Olibanumols A, B, C, H, I, and J from Olibanum, Gum-Resin of Boswellia carterii, and Inhibitors of Nitric Oxide Production in Lipopolysaccharide-Activated Mouse Peritoneal Macrophages
- Medicinal Flowers. XXX. Eight New Glycosides, Everlastosides F—M, from the Flowers of Helichrysum arenarium
- Triterpenoid Saponins from the Stem Bark of Acanthopanax brachypus HARMS
- Mild Deprotection of Methylene Acetals in Combination with Trimethylsilyl Triflate–2,2′-Bipyridyl