Effects of non-digestible oligosaccharides with differentproperties on growth, osmotic diarrhea, lipid metabolism, fecal hydrolase activity and production of short chain fatty acids of cecal contents in rats.

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Six Wistar male rats (3wk) in each group were raised with the restricted feeding the diets containing 10% of lactulose(LAT), fructooligosaccharide(FOS), galactosylsucrose(GS) or isomaltooligosaccharide(IMO) instead of sucrose to give the equal quantity for 44 days. Blood lipid parameters, osmotic diarrhea, fecal hydrolase activity, and short-chain fatty acids(SCFAs) of cecal content were investigated. Final body weight and blood lipid parameters were not significantly different among 5 groups. LAT and FOS caused osmotic diarrhea, but GS and IMO didn't. Amount of total SCFAs were significantly higher in LAT and FOS than in control, GS and IMO. The activity of β-glucronidase and β-glucosidase were also significantly lower in LAT and FOS than control, GS and IMO. These results demonstrate that the beneficial health effects depend on the difference in digestibility, fermentability and utilization by intestinal microbiota among oligosaccharides.
日本食物繊維学会の論文