A case of pancreatic non-functioning endocrine carcinoma diagnosed with endoscopic ultrasound-guided fine needle aspiration cytology
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<I><B>Background:</B></I> We report a patient diagnosed with a pancreatic endocrine tumor by endoscopic ultrasound-guided fine needle aspiration cytology (EUS-FNAC).<BR><I><B>Case:</B></I> A tumor 23×29 mm was found by abdominal ultrasonography in the pancreatic body of a woman about 50 years old. EUSFNAC was conducted because neither biochemical blood examination nor pancreatic fluid cytology showed any abnormality. Tumor cells showed a large numbers of small clusters or isolated cells with granular nuclear chromatin and an increased nuclear/cytoplasm ratio. Based on cytological findings, we diagnosed a pancreatic endocrine tumor and excised the entire tumor. Histologically, tumor proliferation showed a ribbon or trabecular pattern with capillary vessels. Electron microscopy showed neuroendocrine granules. Immunohistochemistry neuroendocrine differentiation. The tumor had partially infiltrated the surrounding pancreatic tissue or vascular system. Based on histological findings, we diagnosed the lesion as pancreatic nonfunctioning endocrine carcinoma.<BR><B><I>Conclusion</I>:</B> EUS-FNAC is highly valuable diagnostically because it minimizes cell degeneration and supplies abundant cell samples for cytological diagnosis. Accordingly, we consider this method useful in preoperatively diagnosing pancreatic masses.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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