Cytological findings of alveolar rhabdomyosarcoma in body fluids
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概要
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<B><I>Background</I>:</B> We report a case of alveolar rhabdomyosarcoma showing peculiar tumor dissemination. Cytological features of tumor cells in body fluid resemble those of DSRCT.<BR><B><I>Case</I>:</B> A 16-year-old boy admitted for dyspnea on exertion was found to have body fluids accumulated in pleural effusion, pericardial effusion, and ascites. Cytological specimens from pericardial and pleural effusion contained many tightly cohesive clusters of homogenous tumor cells, i. e., small and round with high a N/C ratio. Concentric nuclei showed mild irregularity with finely granular chromatin and inconspicuous nucleoli. Binucleated tumor cells, intracytoplasmic inclusions, and fibrillary material were not identified. Gland-like arrangements and nuclear moldings were occasionally identified. At autopsy, the tumor showed proliferation in an alveolar growth pattern with fibrous stroma mainly in serosal membranes. Tumor cells showed positive immunoreactivity for vimentin, desmin, myoglobin, and myogenin. Chromosomal analysis showed chimera gene PAX3-FKHR. Based on these findings, we diagnosed the tumor as alveolar rhabdomyosarcoma.<BR><B><I>Conclusions</I>:</B> It is difficult to make a definite diagnosis of small round cell tumors are difficult to diagnose definitively based on cytological findings alone. It is thus essential in correctly diagnosing these tumors to evaluate clinical data, histological and immunohistochemical findings, and chromosomal analysis.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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