Cytological differential diagnosis of follicular lymphoma grade 1 from reactive follicular hyperplasia-Focusing on distinctive features observed by Papanicolaou staining and immunocytochemical staining of bcl-2 protein-:Focusing on distinctive features ob
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<B><I>Objective</I>:</B> We analyzed cytomorphological differential diagnosis between follicular lymphoma (FL) grade 1 and reactive follicular hyperplasia in Papanicolaou (Pap.) smears and the advantage of immunocytochemical analysis of bcl-2 for differentially diagnosing of FL grade 1 Study Design: Ten cases of reactive follicular hyperplasia and 20 cases of FL Grade 1 were screened by ×40 objective microscopy and identified with ×100 objective microscopy. The percentage of bcl-2 positive cells was also calculated.<BR><B><I>Results</I>:</B> Screening showed that FL grade 1 showed 1) the high appearance of two-nuclei-like cleaved cells and 2) none or few tingible body macrophages compared to reactive follicular hyperplasia. Identification analysis showed that 1) approximately half of FL Grade 1 cases showed similar appearance of individual cells to those of reactive follicular hyperplasia and 2) nucleoli larger than one, μm and cleaved nuclei were high in number, and bcl-2 protein was highly positive in FL grade 1.<BR><B><I>Conclusion</I>:</B> Cytomorphological differential diagnosis of FL grade 1 from reactive follicular hyperplasia is relatively difficult. We found that two-nuclei-like cleaved cells and nucleoli in small lymphocytes observed by ×40 objective microscopy were high in number in diagnosing of FL grade 1 in Pap smears.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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