Goblet cell carcinoid of the rectum: A case report.:A case report
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概要
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<B><I>Background</I>:</B> Goblet cell carcinoid, a rare tumor mainly observed in the appendix, must be differentiated from typical carcinoid tumors because of the aggressiveness. We report characteristic cytological features important for diagnosis, together with other morphological findings, in a case of rectal goblet cell carcinoid.<BR><B><I>Case</I>:</B> A 71-year-old man undergoing a Miles operation for a rectal tumor was found, in imprint cytology to have medinm-sized round to oval cells in a solid sheet with rosette formation. Tumor cells had eccentric, round nuclei with low-grade atypia. Chromatin was finely granular and nuclear features were comparable to those of typical carcinoid. The cytoplasm was reticular, and stained light green with accumulated mucin was detected. Tissue section showed 2 different cellular components of classic carcinoid and signet ring cells. Immunohistochemically, tumor cells were positive for neural differentiation markers, cytokeratin (AE 1/AE 3), Muc 1, and Muc 2. Dense-core neurosecretory granules and mucin vesicles coexistent in tumor cells both in double staining and electron-microscopy.<BR><B><I>Conclusion</I>:</B> In addition to typical carcinoid-like nuclear features, mucin accumulation in the cytoplasm is important in cytologically diagnosing goblet cell carcinoid.
- 特定非営利活動法人 日本臨床細胞学会の論文
特定非営利活動法人 日本臨床細胞学会 | 論文
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